Signaling for death: tyrosine phosphorylation in the response to glucose deprivation
نویسندگان
چکیده
1 Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA and 2 Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA * Corresponding author. Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Bldg 76-353F, Cambridge, MA 02139, USA. Tel.: þ 1 617 258 8949; Fax: þ 1 617 258 0225; E-mail: [email protected]
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The Time Course of JNK and P38 Activation in Cerebellar Granule Neurons following Glucose Deprivation and BDNF Treatment
Low glucose condition induces neuronal cell-death via intracellular mechanisms including mitogen-activated protein kinases (MAPK) signaling pathways. It has been shown that low glucose medium decreases neuronal survival in cerebellar granule neurons (CGNs). In this study, we have examined the activation of JNK, p38kinase and ERK1/2 pathways in low glucose medium in CGNs. The CGNs were prepared ...
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Low glucose condition induces neuronal cell-death via intracellular mechanisms including mitogen-activated protein kinases (MAPK) signaling pathways. It has been shown that low glucose medium decreases neuronal survival in cerebellar granule neurons (CGNs). In this study, we have examined the activation of JNK, p38kinase and ERK1/2 pathways in low glucose medium in CGNs. The CGNs were prepared ...
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